Protection and reversion role of a pure stilbene extract from grapevine shoot and its major compounds against an induced oxidative stress

Sulfur dioxide is a controversial preservative used in winemaking. Given its potential toxicity, it of great interest to find alternatives aimed at replacing or reducing sulfur dioxide. The objective was assess the antioxidant effects grapevine-shoot extract with 99% stilbenes (ST-99), major compounds (trans-resveratrol and trans-?-viniferin) their mixture (1:3.9) by measuring reactive oxygen species (ROS) glutathione (GSH) levels vitro. Their ability protect against reverse H2O2 on cells were also studied. results showed that ST-99, followed trans-?-viniferin mixture, able reduce ROS levels, increased GSH content exhibited an induced oxidative stress. Trans-resveratrol significantly reduced only highest concentrations. ST-99 non-cytotoxic concentrations more effective than other compounds, which might be attributed GSH. suggest promising use ST-99.